IGF-1 LR3 vs IGF-1 DES (Des(1-3)IGF-I)
Comparison
IGF-1 LR3 and IGF-1 DES (Des(1-3)IGF-I) are two peptides people frequently compare. IGF-1 LR3 is a modified form of IGF-1 used by bodybuilders for muscle growth, as it stays active in the bloodstream longer than natural IGF-1. Research in animals covers cardiac growth, nerve… IGF-1 DES is a modified form of the natural growth factor IGF-1 that people use for muscle growth and recovery, believed to act more potently in local tissue. It's also studied in animal models for…
| IGF-1 LR3 | IGF-1 DES (Des(1-3)IGF-I) | |
|---|---|---|
| What it is | IGF-1 LR3 is a modified form of IGF-1 used by bodybuilders for muscle growth, as it stays active in the bloodstream longer than natural IGF-1. Research in animals covers cardiac growth, nerve… | IGF-1 DES is a modified form of the natural growth factor IGF-1 that people use for muscle growth and recovery, believed to act more potently in local tissue. It's also studied in animal models for… |
| Primary uses |
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| How it works | Research in animals covers cardiac growth, nerve regeneration, and Alzheimer's models. Not approved for human use; likely WADA-prohibited; evidence mostly from animal studies. | It's also studied in animal models for neuroprotection and gut development. Not approved for human use; prohibited by WADA; sold as a black-market research compound. |
| Common dose | 50-100 mcg, subcutaneous injection, once daily | 50 mcg, subcutaneous injection, once daily |
| FDA status | Not stated in reviewed literature — requires manual verification. One review notes absence of regulatory approval for physique- or performance-related indications and classifies IGF-1 LR3 among… | Not approved for human use. Described in reviewed literature as a black market product available for bodybuilding and never approved for use in humans. |
| Evidence level | Mixed | Human observational |
| Full IGF-1 LR3 page → | Full IGF-1 DES (Des(1-3)IGF-I) page → |