MK-677 (Ibutamoren) vs Ipamorelin
Comparison
MK-677 (Ibutamoren) and Ipamorelin are two peptides people frequently compare. MK-677 (ibutamoren) is an oral compound people take to raise growth hormone and IGF-1 levels for muscle preservation, fat loss, better sleep, and recovery from aging or illness. It works by mimicking… Ipamorelin is a peptide people use to boost their body's own growth hormone output. It's taken for muscle recovery, body composition, better sleep, and recovery after illness or surgery. Not…
| MK-677 (Ibutamoren) | Ipamorelin | |
|---|---|---|
| What it is | MK-677 (ibutamoren) is an oral compound people take to raise growth hormone and IGF-1 levels for muscle preservation, fat loss, better sleep, and recovery from aging or illness. It works by mimicking… | Ipamorelin is a peptide people use to boost their body's own growth hormone output. It's taken for muscle recovery, body composition, better sleep, and recovery after illness or surgery. Not… |
| Primary uses |
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| How it works | It works by mimicking ghrelin to trigger GH release from the pituitary. Not FDA-approved; banned by WADA; studied in clinical trials for sarcopenia and bone health. | It's taken for muscle recovery, body composition, better sleep, and recovery after illness or surgery. Not FDA-approved; classified as investigational. |
| Common dose | 10 mg, oral, once daily, taken at night before bed | 200 mcg, subcutaneous injection, once daily, pre-sleep |
| FDA status | Not approved as a drug by the FDA for any indication per the reviewed literature. Reviewed literature notes strict FDA criteria for GH use and describes MK-677 as an investigational compound.… | Not stated in reviewed literature as FDA-approved for any indication. Reviewed literature describes ipamorelin as an unapproved/investigational compound for performance and musculoskeletal… |
| Evidence level | Human RCT | Human RCT |
| Full MK-677 (Ibutamoren) page → | Full Ipamorelin page → |