Sermorelin vs Ipamorelin
Comparison
Sermorelin and Ipamorelin are two peptides people frequently compare. Sermorelin is a peptide people use to stimulate natural growth hormone release for aging-related GH decline, body composition, and recovery. It works by activating the same pituitary receptor as the… Ipamorelin is a peptide people use to boost their body's own growth hormone output. It's taken for muscle recovery, body composition, better sleep, and recovery after illness or surgery. Not…
| Sermorelin | Ipamorelin | |
|---|---|---|
| What it is | Sermorelin is a peptide people use to stimulate natural growth hormone release for aging-related GH decline, body composition, and recovery. It works by activating the same pituitary receptor as the… | Ipamorelin is a peptide people use to boost their body's own growth hormone output. It's taken for muscle recovery, body composition, better sleep, and recovery after illness or surgery. Not… |
| Primary uses |
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| How it works | It works by activating the same pituitary receptor as the natural hormone that triggers GH pulses. Previously FDA-approved; now only available through compounding; banned by WADA in sport. | It's taken for muscle recovery, body composition, better sleep, and recovery after illness or surgery. Not FDA-approved; classified as investigational. |
| Common dose | 200-300 mcg, subcutaneous injection, daily, before bed | 200 mcg, subcutaneous injection, once daily, pre-sleep |
| FDA status | Not stated in reviewed literature — requires manual verification | Not stated in reviewed literature as FDA-approved for any indication. Reviewed literature describes ipamorelin as an unapproved/investigational compound for performance and musculoskeletal… |
| Evidence level | Human RCT | Human RCT |
| Full Sermorelin page → | Full Ipamorelin page → |