Thymosin Alpha-1 vs TB-500
Comparison
Thymosin Alpha-1 and TB-500 are two peptides people frequently compare. Thymosin Alpha-1 is an immune-modulating peptide widely used in other countries for hepatitis B, sepsis, cancer support, and COVID-19, though it is restricted from compounding in the USA. It works by… TB-500 is a peptide people use to speed recovery from tendon, muscle, and wound injuries, and to support athletic performance. It works by activating pathways that promote the formation of new blood…
| Thymosin Alpha-1 | TB-500 | |
|---|---|---|
| What it is | Thymosin Alpha-1 is an immune-modulating peptide widely used in other countries for hepatitis B, sepsis, cancer support, and COVID-19, though it is restricted from compounding in the USA. It works by… | TB-500 is a peptide people use to speed recovery from tendon, muscle, and wound injuries, and to support athletic performance. It works by activating pathways that promote the formation of new blood… |
| Primary uses |
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| How it works | It works by enhancing the body's T-cell response to fight infections and cancer. Not FDA-approved; restricted from compounding; approved and used clinically in Asia and Europe. | It works by activating pathways that promote the formation of new blood vessels and tissue repair. Not FDA-approved; banned by WADA; sold as a gray-market research compound. |
| Common dose | 900 mcg, subcutaneous injection, twice per week | 2.0-2.5 mg, subcutaneous injection, twice per week |
| FDA status | As of 2023, the FDA has restricted Tα1 along with 21 additional peptides from compounding. The authors of one review characterize this restriction as 'unfounded' based on clinical trial evidence and… | Not approved for human use by the FDA. Reviewed literature describes TB-500 as an unapproved, investigational compound operating in a 'gray market'. One review notes most of these therapies remain… |
| Evidence level | Human RCT | Mixed |
| Full Thymosin Alpha-1 page → | Full TB-500 page → |