Humanin vs SS-31
Comparison
Humanin and SS-31 are two peptides people frequently compare. Humanin is a small peptide the body makes naturally, mostly in brain and nerve cells. Researchers are studying it as a possible protector of brain and heart cells, and as a biomarker for Alzheimer's,… SS-31 (elamipretide) is a synthetic peptide studied for protecting mitochondria — the energy generators in cells — from damage in diseases like heart failure, kidney injury, and rare mitochondrial…
| Humanin | SS-31 | |
|---|---|---|
| What it is | Humanin is a small peptide the body makes naturally, mostly in brain and nerve cells. Researchers are studying it as a possible protector of brain and heart cells, and as a biomarker for Alzheimer's,… | SS-31 (elamipretide) is a synthetic peptide studied for protecting mitochondria — the energy generators in cells — from damage in diseases like heart failure, kidney injury, and rare mitochondrial… |
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| How it works | Researchers are studying it as a possible protector of brain and heart cells, and as a biomarker for Alzheimer's, diabetes, and age-related decline. No FDA-approved use yet; the research is still at… | It works by binding to a key mitochondrial membrane component and reducing oxidative damage. Not FDA-approved for commercial use; active Phase 2/3 trials ongoing. |
| Common dose | 2 mg, subcutaneous injection, 3x per week | 2 mg, subcutaneous injection, daily |
| FDA status | Not stated in reviewed literature — requires manual verification | Not stated in reviewed literature — requires manual verification. Abstract PMID 41966639 characterizes SS-31 among peptides operating in a 'gray market' of unapproved compounds marketed direct to… |
| Evidence level | Human observational | Human observational |
| Full Humanin page → | Full SS-31 page → |